USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: NFH_HUMAN USC-OGP 2-DE database:  NFH_HUMAN NFH_HUMAN General information about the entry View entry in simple text format Entry name NFH_HUMAN Primary accession number P12036 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Neurofilament heavy polypeptide; Short=NF-H; AltName: Full=200 kDa neurofilament protein; AltName: Full=Neurofilament triplet H protein;. Gene name Name=NEFH Synonyms=KIAA0845, NFH Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1179: pI=5.29; Mw=44651 Cross-references UniProtKB/Swiss-Prot P12036; NFH_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name NFH_HUMAN Primary accession number P12036 Secondary accession number(s) B4DYY4 Q96HF8 Q9UJS7 Q9UQ14 Sequence was last modified on  March 24, 2009 (version 4) Annotations were last modified on  March 15, 2017 (version 171) Name and origin of the protein Description RecName: Full=Neurofilament heavy polypeptide; Short=NF-H; AltName: Full=200 kDa neurofilament protein; AltName: Full=Neurofilament triplet H protein; Gene name Name=NEFH Synonyms=KIAA0845, NFH Encoded on Name=NEFH; Synonyms=KIAA0845, NFH Keywords Alternative splicing; Amyotrophic lateral sclerosis; Charcot-Marie-Tooth disease; Coiled coil; Complete proteome; Cytoplasm; Disease mutation; Intermediate filament; Neurodegeneration; Neuropathy; Phosphoprotein; Polymorphism; Reference proteome; Repeat. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X15306; CAA33366.1; -; Genomic_DNA EMBL X15307; CAA33366.1; JOINED; Genomic_DNA EMBL X15308; CAA33366.1; JOINED; Genomic_DNA EMBL X15309; CAA33366.1; JOINED; Genomic_DNA EMBL AF203032; AAF13722.1; -; mRNA EMBL AB020652; BAA74868.2; ALT_INIT; mRNA EMBL AK302660; BAG63896.1; ALT_INIT; mRNA EMBL AC000035; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC008648; AAH08648.1; -; mRNA EMBL BC073969; AAH73969.1; -; mRNA PIR S00979; QFHUH; . RefSeq NP_066554.2; NM_021076.3; . UniGene Hs.198760; -; . ProteinModelPortal P12036; -; . SMR P12036; -; . BioGrid 110819; 22; . IntAct P12036; 14; . STRING 9606.ENSP00000311997; -; . iPTMnet P12036; -; . PhosphoSitePlus P12036; -; . SwissPalm P12036; -; . BioMuta NEFH; -; . DMDM 226726294; -; . UCD-2DPAGE P12036; -; . EPD P12036; -; . MaxQB P12036; -; . PaxDb P12036; -; . PeptideAtlas P12036; -; . PRIDE P12036; -; . Ensembl ENST00000310624; ENSP00000311997; ENSG00000100285; . GeneID 4744; -; . KEGG hsa:4744; -; . UCSC uc003afo.4; human. [P12036-1]; . CTD 4744; -; . DisGeNET 4744; -; . GeneCards NEFH; -; . H-InvDB HIX0016351; -; . HGNC HGNC:7737; NEFH; . HPA CAB007786; -; . HPA HPA061615; -; . MalaCards NEFH; -; . MIM 105400; phenotype; . MIM 162230; gene; . MIM 616924; phenotype; . neXtProt NX_P12036; -; . Orphanet 803; Amyotrophic lateral sclerosis; . PharmGKB PA31540; -; . eggNOG ENOG410IGME; Eukaryota; . eggNOG ENOG410XPTM; LUCA; . HOGENOM HOG000230977; -; . HOVERGEN HBG013015; -; . InParanoid P12036; -; . KO K04574; -; . OrthoDB EOG091G12MK; -; . PhylomeDB P12036; -; . TreeFam TF330122; -; . SIGNOR P12036; -; . ChiTaRS NEFH; human; . GenomeRNAi 4744; -; . PRO PR:P12036; -; . Proteomes UP000005640; Chromosome 22; . Bgee ENSG00000100285; -; . CleanEx HS_NEFH; -; . Genevisible P12036; HS; . GO GO:0030424; C:axon; TAS:UniProtKB; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005739; C:mitochondrion; IEA:Ensembl; . GO GO:0043209; C:myelin sheath; IEA:Ensembl; . GO GO:0097418; C:neurofibrillary tangle; IDA:BHF-UCL; . GO GO:0005883; C:neurofilament; NAS:UniProtKB; . GO GO:0014069; C:postsynaptic density; IEA:Ensembl; . GO GO:0070840; F:dynein complex binding; TAS:BHF-UCL; . GO GO:0019894; F:kinesin binding; TAS:BHF-UCL; . GO GO:0008017; F:microtubule binding; TAS:BHF-UCL; . GO GO:0030674; F:protein binding; bridging; ISS:BHF-UCL GO GO:0019901; F:protein kinase binding; IPI:BHF-UCL; . GO GO:0005200; F:structural constituent of cytoskeleton; ISS:BHF-UCL; . GO GO:0005198; F:structural molecule activity; IMP:BHF-UCL; . GO GO:0061564; P:axon development; IMP:BHF-UCL; . GO GO:0007409; P:axonogenesis; TAS:BHF-UCL; . GO GO:0030031; P:cell projection assembly; TAS:BHF-UCL; . GO GO:0000226; P:microtubule cytoskeleton organization; IEA:Ensembl; . GO GO:0033693; P:neurofilament bundle assembly; IMP:BHF-UCL; . GO GO:0048936; P:peripheral nervous system neuron axonogenesis; IEA:Ensembl; . GO GO:1902513; P:regulation of organelle transport along microtubule; IMP:BHF-UCL; . InterPro IPR010790; DUF1388; . InterPro IPR001664; IF; . InterPro IPR018039; Intermediate_filament_CS; . InterPro IPR033183; NF-H; . PANTHER PTHR23214; PTHR23214; 1; . Pfam PF07142; DUF1388; 9; . Pfam PF00038; Filament; 1; . SMART SM01391; Filament; 1; . PROSITE PS00226; IF; 1; .

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